InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DIXDC1

Summary

InnateDB Gene

IDBG-71136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIXDC1

Gene Name

DIX domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000150764

Encoded Proteins

IDBP-383072

DIX domain containing 1

IDBP-601481

DIX domain containing 1

IDBP-812419

DIX domain containing 1

IDBP-812423

DIX domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:111927144-112022584

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000440460	ENSP00000394352
ENST00000529225	ENSP00000434130
ENST00000528399
ENST00000526500
ENST00000530645
ENST00000526418
ENST00000614104	ENSP00000479434
ENST00000615255	ENSP00000480808
ENST00000618522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0021695	cerebellar cortex development
GO:0021795	cerebral cortex cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021846	cell proliferation in forebrain
GO:0021869	forebrain ventricular zone progenitor cell division
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030900	forebrain development
GO:0032956	regulation of actin cytoskeleton organization
GO:0043010	camera-type eye development
GO:0045665	negative regulation of neuron differentiation
GO:0046328	regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0050772	positive regulation of axonogenesis
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0043679	axon terminus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032064

View Gene Order

ENSBTAG00000008665

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q155Q3

TrEMBL

UniProt Splice Variant

Entrez Gene

85458

UniGene

Hs.599801 Hs.655626

RefSeq

NM_001278542 NM_001037954 NM_033425 XM_005277726 XM_005277728

HUGO

HGNC:23695

OMIM

610493

CCDS

CCDS60957 CCDS73381 CCDS73382

HPRD

16804

IMGT

EMBL

AB051522 AK055899 AP000907 BC033034 BC035509 BC041626 BC048294 BC064479 BC128600 CH471065 DQ642016

GenPept

AAH33034 AAH35509 AAH41626 AAH48294 AAH64479 AAI28601 ABG25914 BAB21826 BAB71039 EAW67171

RNA Seq Atlas

85458