Version 5.4
Homo sapiens Gene: S100A13
Summary
InnateDB Gene IDBG-102736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A13
Gene Name S100 calcium binding protein A13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189171
Encoded Proteins
IDBP-102738
S100 calcium binding protein A13
IDBP-102740
S100 calcium binding protein A13
IDBP-245286
S100 calcium binding protein A13
IDBP-245288
S100 calcium binding protein A13
IDBP-388671
S100 calcium binding protein A13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153618787-153634092
Strand Reverse strand
Band q21.3
Transcripts
ENST00000339556 ENSP00000344822
ENST00000368699 ENSP00000357688
ENST00000392623 ENSP00000376399
ENST00000392622 ENSP00000376398
ENST00000440685 ENSP00000392767
ENST00000476133
ENST00000491177
ENST00000497086
ENST00000484413
ENST00000472233
ENST00000469931
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0017134 fibroblast growth factor binding
GO:0042803 protein homodimerization activity
GO:0050786 RAGE receptor binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043303 mast cell degranulation
GO:0046688 response to copper ion
GO:0050663 cytokine secretion
GO:0050703 interleukin-1 alpha secretion
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042629 mast cell granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042312
View Gene Order
ENSBTAG00000021378
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737210
RefSeq NM_001024210 NM_001024211 NM_001024212 NM_001024213 NM_005979 XM_005245434
HUGO
OMIM
CCDS CCDS30874
HPRD 03586
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca