Homo sapiens Gene: TPI1
Summary
InnateDB Gene IDBG-15360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPI1
Gene Name triosephosphate isomerase 1
Synonyms HEL-S-49; TIM; TPI; TPID;
Species Homo sapiens
Ensembl Gene ENSG00000111669
Encoded Proteins
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
triosephosphate isomerase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6867119-6870948
Strand Forward strand
Band p13.31
Transcripts
ENST00000229270 ENSP00000229270
ENST00000396705 ENSP00000379933
ENST00000488464 ENSP00000475620
ENST00000493987 ENSP00000475364
ENST00000462761 ENSP00000475184
ENST00000495834 ENSP00000475829
ENST00000482209
ENST00000474253
ENST00000535434 ENSP00000443599
ENST00000613953 ENSP00000484435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004807 triose-phosphate isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006098 pentose-phosphate shunt
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0019682 glyceraldehyde-3-phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fructose and mannose metabolism pathway
Inositol phosphate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000365 NM_001159287 NM_001258026
HUGO
OMIM
CCDS CCDS53740 CCDS58206 CCDS8566
HPRD 01833
IMGT
EMBL
GenPept
RNA Seq Atlas