Version 5.4
Homo sapiens Gene: TPI1
Summary
InnateDB Gene IDBG-15360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPI1
Gene Name triosephosphate isomerase 1
Synonyms HEL-S-49; TIM; TPI; TPID
Species Homo sapiens
Ensembl Gene ENSG00000111669
Encoded Proteins
IDBP-15362
triosephosphate isomerase 1
IDBP-236942
triosephosphate isomerase 1
IDBP-806913
triosephosphate isomerase 1
IDBP-806914
triosephosphate isomerase 1
IDBP-806915
triosephosphate isomerase 1
IDBP-806916
triosephosphate isomerase 1
IDBP-600116
triosephosphate isomerase 1
IDBP-806917
triosephosphate isomerase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6867119-6870948
Strand Forward strand
Band p13.31
Transcripts
ENST00000229270 ENSP00000229270
ENST00000396705 ENSP00000379933
ENST00000488464 ENSP00000475620
ENST00000493987 ENSP00000475364
ENST00000462761 ENSP00000475184
ENST00000495834 ENSP00000475829
ENST00000482209
ENST00000474253
ENST00000535434 ENSP00000443599
ENST00000613953 ENSP00000484435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004807 triose-phosphate isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006098 pentose-phosphate shunt
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0019682 glyceraldehyde-3-phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023456
View Gene Order
ENSBTAG00000019782
Not yet available
Pathways
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00562
Inositol phosphate metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P60174
TrEMBL U3KPS5 U3KPZ0 U3KQF3 V9HWK1
UniProt Splice Variant
Entrez Gene 7167
UniGene
RefSeq NM_000365 NM_001159287 NM_001258026
HUGO HGNC:12009
OMIM 190450
CCDS CCDS53740 CCDS58206 CCDS8566
HPRD
IMGT
EMBL AK298809 AK313282 BC007086 BC007812 BC009329 BC011611 BC015100 BC017165 BC017917 BC070129 CH471116 CR541702 EU794668 J04603 M10036 U47924 X69723
GenPept AAB51316 AAB59511 AAH07086 AAH07812 AAH09329 AAH11611 AAH15100 AAH17165 AAH17917 AAH70129 AAN86636 ACJ13722 BAG36090 BAH12874 CAA49379 CAG46503 EAW88722 EAW88723
RNA Seq Atlas 7167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca