Version 5.4
Homo sapiens Gene: TWF1
Summary
InnateDB Gene IDBG-28090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWF1
Gene Name twinfilin, actin-binding protein, homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151239
Encoded Proteins
IDBP-239403
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-588701
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-589437
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-598885
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-586982
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-586718
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-593855
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-600332
twinfilin, actin-binding protein, homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:43793723-43806375
Strand Reverse strand
Band q12
Transcripts
ENST00000395510 ENSP00000378886
ENST00000552521 ENSP00000448750
ENST00000547459 ENSP00000446665
ENST00000548315 ENSP00000449428
ENST00000551789
ENST00000546662 ENSP00000448221
ENST00000550371 ENSP00000448682
ENST00000548403 ENSP00000446696
ENST00000546506 ENSP00000448230
ENST00000547564
ENST00000547961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030837 negative regulation of actin filament polymerization
GO:0042989 sequestering of actin monomers
GO:0043538 regulation of actin phosphorylation
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030175 filopodium
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022451
View Gene Order
ENSBTAG00000020938
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.189075 Hs.313056
RefSeq NM_001242397 NM_002822
HUGO
OMIM
CCDS CCDS31780 CCDS55818
HPRD 10174
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca