Version 5.4
Homo sapiens Gene: PIP5K1B
Summary
InnateDB Gene IDBG-69048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIP5K1B
Gene Name phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Synonyms MSS4; STM7
Species Homo sapiens
Ensembl Gene ENSG00000107242
Encoded Proteins
IDBP-69050
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
IDBP-69054
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
IDBP-372234
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
IDBP-372238
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
IDBP-595788
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
IDBP-590084
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:68705414-69009176
Strand Forward strand
Band q21.11
Transcripts
ENST00000265382 ENSP00000265382
ENST00000377284 ENSP00000366498
ENST00000437200 ENSP00000398587
ENST00000440050 ENSP00000411477
ENST00000472907
ENST00000474356
ENST00000478500 ENSP00000435778
ENST00000541509 ENSP00000438082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0001931 uropod
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024867
View Gene Order
ENSBTAG00000009917
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
NetPath_12
BCR pathway
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_200668
WNT mediated activation of DVL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_111217
Metabolism pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
plexind1_pathway
Plexin-D1 Signaling
rac1_pathway
RAC1 signaling pathway
wnt_canonical_pathway
Canonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534371
RefSeq NM_001278253 NM_003558 XM_005252261 XM_005252262 XM_006717300 XM_006717301
HUGO
OMIM
CCDS CCDS65063 CCDS6624
HPRD 04121
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca