Homo sapiens Gene: NRG3
Summary
InnateDB Gene IDBG-80642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRG3
Gene Name neuregulin 3
Synonyms HRG3; pro-NRG3;
Species Homo sapiens
Ensembl Gene ENSG00000185737
Encoded Proteins
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
neuregulin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81875314-82987179
Strand Forward strand
Band q23.1
Transcripts
ENST00000372142 ENSP00000361215
ENST00000372141 ENSP00000361214
ENST00000404547 ENSP00000384796
ENST00000404576 ENSP00000385804
ENST00000555784 ENSP00000451858
ENST00000556918 ENSP00000451376
ENST00000545131 ENSP00000441201
ENST00000537893 ENSP00000440377
ENST00000602794 ENSP00000473669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007389 pattern specification process
GO:0009790 embryo development
GO:0030879 mammary gland development
GO:0035556 intracellular signal transduction
GO:0060596 mammary placode formation
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
G-secretase mediated erbb4 signaling pathway [Biocarta view]
PID NCI
ErbB4 signaling events
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL D9ZHQ8
UniProt Splice Variant
Entrez Gene 10718
UniGene Hs.125119
RefSeq NM_001010848 NM_001165972 NM_001165973
HUGO HGNC:7999
OMIM 605533
CCDS CCDS31233 CCDS53547
HPRD 16115
IMGT
EMBL AC010157 AL096705 AL096706 AL096863 AL096864 AL136085 AL354749 AL356129 AL358552 AL391478 AL513204 AL513316 AL589782 HM068885
GenPept ADK90032
RNA Seq Atlas 10718