Homo sapiens Gene: SLC29A1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-89061.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SLC29A1 | ||||||||||||||||||||||
Gene Name | solute carrier family 29 (nucleoside transporters), member 1 | ||||||||||||||||||||||
Synonyms | ENT1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000112759 | ||||||||||||||||||||||
Encoded Proteins |
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:44219505-44234151 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p21.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
Transport of vitamins, nucleosides, and related molecules pathway
Transmembrane transport of small molecules pathway
SLC-mediated transmembrane transport pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.25450 | ||||||||||||||||||||||
RefSeq | NM_001078174 NM_001078175 NM_001078176 NM_001078177 NM_004955 XM_005248875 XM_005248876 XM_005248878 XM_005248879 XM_005248880 XM_005248881 XM_005248882 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS4908 | ||||||||||||||||||||||
HPRD | 03724 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||