Homo sapiens Gene: SLC29A1
Summary
InnateDB Gene IDBG-89061.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC29A1
Gene Name solute carrier family 29 (nucleoside transporters), member 1
Synonyms ENT1;
Species Homo sapiens
Ensembl Gene ENSG00000112759
Encoded Proteins
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
solute carrier family 29 (nucleoside transporters), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:44219505-44234151
Strand Forward strand
Band p21.1
Transcripts
ENST00000371740 ENSP00000360805
ENST00000371755 ENSP00000360820
ENST00000371731 ENSP00000360796
ENST00000371724 ENSP00000360789
ENST00000371713 ENSP00000360778
ENST00000371708 ENSP00000360773
ENST00000393844 ENSP00000377427
ENST00000393841 ENSP00000377424
ENST00000427851 ENSP00000392668
ENST00000472176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005337 nucleoside transmembrane transporter activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006810 transport
GO:0007595 lactation
GO:0015858 nucleoside transport
GO:0015862 uridine transport
GO:0030431 sleep
GO:0055085 transmembrane transport
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
GO:0071456 cellular response to hypoxia
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Transport of vitamins, nucleosides, and related molecules pathway
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.25450
RefSeq NM_001078174 NM_001078175 NM_001078176 NM_001078177 NM_004955 XM_005248875 XM_005248876 XM_005248878 XM_005248879 XM_005248880 XM_005248881 XM_005248882
HUGO
OMIM
CCDS CCDS4908
HPRD 03724
IMGT
EMBL
GenPept
RNA Seq Atlas